The ARNT Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ARNT. This antibody recognizes Human, Mouse, and Rat antigen. The ARNT Antibody has been validated for the following applications: ELISA, Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
Function: Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.
Subunit Structure: Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with AHR, AHRR, HIF1A and EPAS1/HIF2A as well as with other bHLH proteins. Interacts with TACC3 (By similarity). Interacts with NOCA7. Heterodimer with HIF1A